2-Methylthioadenosine diphosphate trisodium salt

Catalog #: 1624
12 Citations Datasheet / COA / SDS

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1624/10

2-Methylthioadenosine diphosphate trisodium salt | CAS No. 475193-31-8 | P2Y Receptor Agonists

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Description: Potent agonist at P2Y1, P2Y12 and P2Y13

Alternative Names: 2-(Methylthio)adenosine 5'-diphosphate,2-Methylthio-ADP,MeSADP

Chemical Name: 2-(Methylthio)adenosine-5'-(trihydrogen diphosphate) trisodium salt

Purity: ≥98%

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Product Details

Citations (12)

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Biological Activity

2-Methylthioadenosine diphosphate trisodium salt is a potent purinergic agonist displaying selectivity for P2Y₁, P2Y₁₂ and P2Y₁₃ receptors (pEC₅₀ = 8.29 and 9.05 for P2Y₁ and P2Y₁₂, EC₅₀ = 19 nM for P2Y₁₃). Induces aggregation of, and inhibits cAMP accumulation in, platelets in vitro.

Technical Data

M.Wt:

539.24

Formula:

C₁₁H₁₄N₅Na₃O₁₀P₂S

Solubility:

Soluble in water (supplied pre-dissolved at a concentration of 10mM)

Purity:

≥98%

Storage:

Store at -20°C

CAS No:

475193-31-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

2-Methylthioadenosine[β-³²P]diphosphate. An agonist and radioligand for the receptor that inhibits the accumulation of cyclic AMP in intact blood platelets.
Macfarlane et al.
J.Clin.Invest., 1983;71:420
P2Y₁₃: identification and characterization of a novel Gαi-coupled ADP receptor from human and mouse.
Zhang et al.
J.Pharmacol.Exp.Ther., 2002;301:705
A retrospective of recombinant P2Y receptor subtypes and their pharmacology.
Sak and Webb
Arch.Biochem.Biophys., 2002;397:131

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Citations for 2-Methylthioadenosine diphosphate trisodium salt

The citations listed below are publications that use Tocris products. Selected citations for 2-Methylthioadenosine diphosphate trisodium salt include:

12 Citations: Showing 1 - 10

Platelet-derived β2M regulates monocyte inflammatory responses.
Authors: Hilt Et al.
JCI Insight 2019;4
P2Y1 Purinergic Receptor Modulate Axon Initial Segment Initial Development.
Authors: Zhang Et al.
Front Cell Neurosci 2019;13:152
The P2Y12 Receptor Antagonist Ticagrelor Reduces Lysosomal pH and Autofluorescence in Retinal Pigmented Epithelial Cells From the ABCA4-/- Mouse Model of Retinal Degeneration.
Authors: Lu Et al.
Front Pharmacol 2018;9:242
Microglial Ramification, Surveillance, and Interleukin-1β Release Are Regulated by the Two-Pore Domain K+ Channel THIK-1.
Authors: Madry Et al.
Neuron 2018;97:299
PDK1 governs thromboxane generation and thrombosis in platelets by regulating activation of Raf1 in the MAPK pathway.
Authors: Manne Et al.
J Thromb Haemost 2018;16:1211
Glutamate Receptor Interacting Protein 1 Mediates Platelet Adhesion and Thrombus Formation.
Authors: Modjeski Et al.
PLoS One 2016;11:e0160638
Agonist-bound structure of the human P2Y12 receptor.
Authors: Zhang Et al.
Purinergic Signal 2014;509:119
The enteric nervous system of P2Y13 receptor null mice is resistant against high-fat-diet- and palmitic-acid-induced neuronal loss.
Authors: Voss Et al.
Br J Pharmacol 2014;10:455
Pharmacological characterization of the P2 receptors profile in the podocytes of the freshly isolated rat glomeruli.
Authors: Ilatovskaya Et al.
Am J Physiol Cell Physiol 2013;305:C1050
A comprehensive strategy to discover inhibitors of the translesion synthesis DNA polymerase κ.
Authors: Yamanaka Et al.
PLoS One 2012;7:e45032

Astrocytes modulate neural network activity by Ca2+-dependent uptake of extracellular K+.
Authors: Wang Et al.
Nature 2012;5:ra26

Evidence for the possible involvement of the P2Y(6) receptor in Ca (2+) mobilization and Ins secretion in mouse pancreatic islets.
Authors: Ohtani Et al.
Purinergic Signal 2008;4:365

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