1-Naphthyl PP1

Catalog #: 3063
6 Citations Datasheet / COA / SDS

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3063/10
3063/50

1-Naphthyl PP1 | CAS No. 221243-82-9 | Src Family Kinase Inhibitors

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Description: Src family kinase inhibitor; also inhibits c-Abl

Alternative Names: 1-NA-PP 1

Chemical Name: 1-(1,1-Dimethylethyl)-3-(1-naphthalenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Purity: ≥99%

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Product Details

Citations (6)

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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

1-Naphthyl PP1 is a selective inhibitor of src family kinases v-Src and c-Fyn as well as the tyrosine kinase c-Abl. (IC₅₀ values are 1.0, 0.6, 0.6, 18 and 22 μM for v-Src, c-Fyn, c-Abl, CDK2 and CAMK II respectively). Preferentially inhibits mutant over wild-type kinases (IC₅₀ values are 1.5 vs 1000 nM for I338G v-src and v-src respectively).

Technical Data

M.Wt:

317.39

Formula:

C₁₉H₁₉N₅

Solubility:

Soluble to 20 mM in DMSO

Purity:

≥99%

Storage:

Store at +4°C

CAS No:

221243-82-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

A chemical switch for inhibitor-sensitive alleles of any protein kinase.
Bishop et al.
Nature, 2000;407:395
Generation of monospecific nanomolar tyrosine kinase inhibitors via a chemical genetic approach.
Bishop et al.
J.Am.Chem.Soc., 1999;121:627

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Citations for 1-Naphthyl PP1

The citations listed below are publications that use Tocris products. Selected citations for 1-Naphthyl PP1 include:

6 Citations: Showing 1 - 6

Unidirectional Eph/ephrin signaling creates a cortical actomyosin differential to drive cell segregation.
Authors: O'Neill Et al.
J Cell Biol 2016;215:217
Ipl1/Aurora-B is necessary for kinetochore restructuring in meiosis I in Saccharomyces cerevisiae.
Authors: Meyer Et al.
Genes Dev 2015;26:2986
Phosphorylation of the Synaptonemal Complex Protein Zip1 Regulates the Crossover/Noncrossover Decision during Yeast Meiosis.
Authors: Chen Et al.
PLoS Biol 2015;13:e1002329
A method for sporulating budding yeast cells that allows for unbiased identification of kinase substrates using stable isotope labeling by amino acids in cell culture.
Authors: Suhandynata Et al.
G3 (Bethesda) 2014;4:2125
Dual mechanisms prevent premature chromosome segregation during meiosis.
Authors: Kim Et al.
Cell Death Dis 2013;27:2139
Using the semi-synthetic epitope system to identify direct substrates of the meiosis-specific budding yeast kinase, Mek1.
Authors: Lo and Hollingsworth
Methods Mol Biol 2011;745:135

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