SR 57227 hydrochloride

Biological Activity

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

1. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
   Fox JT, Sakamuru S, Huang R
   Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8.
2. Spinal 5-HT3 receptors mediate descending facilitation and contribute to behavioral hypersensitivity via a reciprocal neuron-glial signaling cascade.
   Guo W, Miyoshi K, Dubner R, Gu M, Li M, Liu J, Yang J, Zou S, Ren K, Noguchi K, Wei F
   Mol Pain, 2014;10(0):35.
3. SR 57227A: a potent and selective agonist at central and peripheral 5-HT₃ receptors in vitro and in vivo.
   Bachy et al.
   Eur.J.Pharmacol., 1993;237:299
4. 5-HT₃-like receptors in the rat medial prefrontal cortex: further pharmacological characterization.
   Edwards et al.
   Brain Res., 1996;733:21

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