Human NKG2A/CD159a APC-conjugated Antibody Summary
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
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Detection of NKG2A/CD159a in Human Blood Lymphocytes by Flow Cytometry. Human peripheral blood lymphocytes were stained with Mouse Anti-Human NKG2A/CD159a APC-conjugated Mono-clonal Antibody (Catalog # FAB1059A) and Mouse Anti-Human NCAM-1/CD56 PE-conjugated Monoclonal Antibody (Catalog # FAB2408P). Quadrant markers were set based on isotype control antibody staining (Catalog # IC003A). View our protocol for Staining Membrane-associated Proteins.
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Preparation and Storage
- 12 months from date of receipt, 2 to 8 °C as supplied.
Background: NKG2A/CD159a
NKG2A, also known as CD159a, is a type II transmembrane receptor having a single extracellular lectin-like domain and a cytoplasmic ITIM motif. It associates with CD94 and is expressed on NK cells and some activated T cell populations. The NKG2A/CD94 complex delivers an inhibitory signal upon recognition of its ligand, HLA-E.
Product Datasheets
Citations for Human NKG2A/CD159a APC-conjugated Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
13
Citations: Showing 1 - 10
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Oral cancer cell‑derived exosomes modulate natural killer cell activity by regulating the receptors on these cells
Authors: Xueqin Zhu, Xing Qin, Xiaoning Wang, Yingnan Wang, Wei Cao, Jianjun Zhang et al.
International Journal of Molecular Medicine
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Single-cell characterization of anti–LAG-3 and anti–PD-1 combination treatment in patients with melanoma
Authors: Jani Huuhtanen, Henna He Kasanen, Katriina Peltola, Tapio Lönnberg, Virpi Glumoff, Oscar Brück et al.
Journal of Clinical Investigation
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Human fused NKG2D–IL-15 protein controls xenografted human gastric cancer through the recruitment and activation of NK cells
Authors: Yan Chen, Bei Chen, Ti Yang, Weiming Xiao, Li Qian, Yanbing Ding et al.
Cellular & Molecular Immunology
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Efficacy of anti-CD147 chimeric antigen receptors targeting hepatocellular carcinoma
Authors: HC Tseng, W Xiong, S Badeti, Y Yang, M Ma, T Liu, CA Ramos, G Dotti, L Fritzky, JG Jiang, Q Yi, J Guarrera, WX Zong, C Liu, D Liu
Nat Commun, 2020-09-23;11(1):4810.
Species: Human
Sample Types: Whole Cells, Whole Tissue
Applications: Flow Cytometry, IHC -
Between Innate and Adaptive Immune Responses: NKG2A, NKG2C, and CD8? T Cell Recognition of HLA-E Restricted Self-Peptides Acquired in the Absence of HLA-Ia
Authors: WC Pump, T Kraemer, T Huyton, GT Hò, R Blasczyk, C Bade-Doedi
Int J Mol Sci, 2019-03-22;20(6):.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Interferon Alpha Induces Sustained Changes in NK Cell Responsiveness to Hepatitis B Viral Load Suppression In Vivo
PLoS Pathog, 2016-08-03;12(8):e1005788.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Human CD8+ T-cells recognizing peptides from Mycobacterium tuberculosis (Mtb) presented by HLA-E have an unorthodox Th2-like, multifunctional, Mtb inhibitory phenotype and represent a novel human T-cell subset.
Authors: van Meijgaarden K, Haks M, Caccamo N, Dieli F, Ottenhoff T, Joosten S
PLoS Pathog, 2015-03-24;11(3):e1004671.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Human Herpesvirus 8 (HHV8) sequentially shapes the NK cell repertoire during the course of asymptomatic infection and Kaposi sarcoma.
Authors: Dupuy S, Lambert M, Zucman D, Choukem SP, Tognarelli S, Pages C, Lebbe C, Caillat-Zucman S
PLoS Pathog., 2012-01-12;8(1):e1002486.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Binding of excreted and/or secreted products of adult hookworms to human NK cells in Necator americanus-infected individuals from Brazil.
Authors: Teixeira-Carvalho A, Fujiwara RT, Stemmy EJ, Olive D, Damsker JM, Loukas A, Correa-Oliveira R, Constant SL, Bethony JM
Infect. Immun., 2008-10-06;76(12):5810-6.
Species: Human
Sample Types: Whole Cells
Applications: Neutralization -
Autologous antitumor activity by NK cells expanded from myeloma patients using GMP-compliant components.
Authors: Alici E, Sutlu T, Bjorkstrand B, Gilljam M, Stellan B, Nahi H, Quezada HC, Gahrton G, Ljunggren HG, Dilber MS
Blood, 2008-01-11;111(6):3155-62.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Natural killer cells in perinatally HIV-1-infected children exhibit less degranulation compared to HIV-1-exposed uninfected children and their expression of KIR2DL3, NKG2C, and NKp46 correlates with disease severity.
Authors: Ballan WM, Vu BA, Long BR, Loo CP, Michaelsson J, Barbour JD, Lanier LL, Wiznia AA, Abadi J, Fennelly GJ, Rosenberg MG, Nixon DF
J. Immunol., 2007-09-01;179(5):3362-70.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Natural killer cells activated through NKG2D mediate lung ischemia-reperfusion injury
Authors: Daniel R. Calabrese, Emily Aminian, Benat Mallavia, Fengchun Liu, Simon J. Cleary, Oscar A. Aguilar et al.
Journal of Clinical Investigation
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Improving NK cell function in multiple myeloma with NKTR-255, a novel polymer-conjugated human IL-15
Authors: Rafael Alonso Alonso Fernández, Jessica Encinas Mayoral, Laetitia Pierre-Louis, Yao Yao, Yan Xu, Shidai Mu et al.
Blood Advances
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