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GSK 690693

Catalog #: 4144
5 Citations Datasheet / COA / SDS
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4144/10
GSK 690693 | CAS No. 937174-76-0 | Akt (Protein Kinase B) Inhibitors
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Description: Akt kinase inhibitor. Antitumor

Chemical Name: 4-[2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[(3S)-3-piperidinylmethoxy)-1H-imidazo[4,5-c]pyridin-4-yl]-2-methyl-3-butyn-2-ol

Purity: ≥98%

Product Details
Citations (5)
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Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

GSK 690693 is an ATP-competitive pan-Akt kinase inhibitor (IC50 values are 2, 13 and 9 nM of Akt1, 2 and 3 respectively). Also exhibits some inhibition for AMPK, PKA and PAK and PKC isoforms (IC50 < 100 nM). Displays antiproliferative and apoptotic effects in tumor cell lines.

Technical Data

M.Wt:
425.48
Formula:
C21H27N7O3
Solubility:
Soluble to 50 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
937174-76-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold for research purposes only under agreement from GlaxoSmithKline

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Citations for GSK 690693

The citations listed below are publications that use Tocris products. Selected citations for GSK 690693 include:

5 Citations: Showing 1 - 5

  1. Reduction of protein kinase A-mediated phosphorylation of ATXN1-S776 in Purkinje cells delays onset of Ataxia in a SCA1 mouse model.
    Authors: Nissa Et al.
    Neurobiol Dis  2018;116:93-105
  2. Upregulation of Nicotinic Acetylcholine Receptor α4+β2 through a Ligand-Independent PI3Kβ Mechanism That Is Enhanced by TNFα and the Jak2/p38Mapk Pathways.
    Authors: Rogers and Gahring
    J Mol Neurosci  2015;10:e0143319
  3. Orexins protect neuronal cell cultures against hypoxic stress: an involvement of Akt signaling.
    Authors: Soko&#322;owska Et al.
    Stem Cell Reports  2014;52:48
  4. α1β1 integrin/Rac1-dependent mesangial invasion of glomerular capillaries in Alport syndrome.
    Authors: Marisa Et al.
    Am J Pathol  2013;183:1269-1280
  5. Fibroblast growth factor-23 abolishes 1,25-dihydroxyvitamin D3-enhanced duodenal calcium transport in male mice.
    Authors: Khuituan Et al.
    Am J Physiol Endocrinol Metab  2012;302:E903

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