Dibutyryl-cAMP, sodium salt

Biological Activity

Dibutyryl-cAMP sodium salt is a cell-permeable analog of cAMP that activates cAMP-dependent protein kinases and is a phosphodiesterase inhibitor. Combined with other reagents, dibutyryl-cAMP promotes differentiation of neural stem/progenitor cells (NSPCs) and other cell lines and increases survival rates of NSPCs and differentiation into neurons in vivo. Promotes neurite outgrowth in cell cultures. Dibutyryl-cAMP has anti-inflammatory activity and is used to promote wound healing. Choline acetyltransferase and vesicular acetylcholine transporter mRNA are increased in cells treated with dibutyryl-cAMP.

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

1. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
   Fox JT, Sakamuru S, Huang R
   Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8.
2. Inversion of Sonic hedgehog action on its canonical pathway by electrical activity.
   Belgacem Y, Borodinsky L
   Proc Natl Acad Sci U S A, 2015;112(13):4140-5.
3. Transcriptional comparison of human induced and primary midbrain DArgic neurons.
   Xia et al.
   Sci.Rep., 2016;6:20270
4. Protein kinase A induces recruitment of active Na⁺,K⁺-ATPase units to the plasma membrane of rat proximal convoluted tubule cells.
   Carranza et al.
   J.Physiol., 1998;511:235
5. Lack of correlation between activation of cyclic AMP-dependent protein kinase and inhibition of contraction of rat vas deferens by cyclic AMP analogs
   Hei et al.
   Mol.Pharmacol., 1991;39:233
6. Differential expression of dystrophin isoforms and utrophin during dibutyryl-cAMP-induced morphological differentiation of rat brain astrocytes.
   Imamura et al.
   Proc.Natl.Acad.Sci.U.S.A., 1998;95:6139

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